We study a situation that arises in the somatic evolution of cancer. Consider a finite population of replicating cells and a sequence of mutations: type 0 can mutate to type 1, wh...
Colorectal cancer is initiated in colonic crypts as a consequence of alterations leading to the disruption of the normal colonic cellular process. We propose a model, which couple...
Isabel N. Figueiredo, Carlos F. Leal, Tommaso Leon...
In this paper, we introduce a novel objective function for the hierarchical clustering of data from distance matrices, a very relevant task in Bioinformatics. To test the robustnes...
Pritha Mahata, Wagner Costa, Carlos Cotta, Pablo M...
Background: DNA methylation is an important epigenetic modification of the genome. Abnormal DNA methylation may result in silencing of tumor suppressor genes and is common in a va...
A wide variety of practical problems related to the interaction of agents can be examined using biological metaphors. This paper applies the theory of G-networks to agent systems b...