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» The evolutionary capacity of protein structures
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BMCBI
2007
144views more  BMCBI 2007»
13 years 7 months ago
Accelerated search for biomolecular network models to interpret high-throughput experimental data
Background: The functions of human cells are carried out by biomolecular networks, which include proteins, genes, and regulatory sites within DNA that encode and control protein e...
Suman Datta, Bahrad A. Sokhansanj
BMCBI
2006
118views more  BMCBI 2006»
13 years 7 months ago
Predicting the effect of missense mutations on protein function: analysis with Bayesian networks
Background: A number of methods that use both protein structural and evolutionary information are available to predict the functional consequences of missense mutations. However, ...
Chris J. Needham, James R. Bradford, Andrew J. Bul...
ATAL
2006
Springer
13 years 11 months ago
Efficient agent-based models for non-genomic evolution
Modeling dynamical systems composed of aggregations of primitive proteins is critical to the field of astrobiological science, which studies early evolutionary structures dealing ...
Nachi Gupta, Adrian K. Agogino, Kagan Tumer
BMCBI
2008
112views more  BMCBI 2008»
13 years 7 months ago
A simplified approach to disulfide connectivity prediction from protein sequences
Background: Prediction of disulfide bridges from protein sequences is useful for characterizing structural and functional properties of proteins. Several methods based on differen...
Marc Vincent, Andrea Passerini, Matthieu Labb&eacu...
BMCBI
2008
114views more  BMCBI 2008»
13 years 7 months ago
WSPMaker: a web tool for calculating selection pressure in proteins and domains using window-sliding
Background: In the study of adaptive evolution, it is important to detect the protein coding sites where natural selection is acting. In general, the ratio of the rate of non-syno...
Yong Seok Lee, Tae-Hyung Kim, Tae-Wook Kang, Won-H...