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BMCBI
2011
13 years 2 months ago
Accurate statistics for local sequence alignment with position-dependent scoring by rare-event sampling
Background: Molecular database search tools need statistical models to assess the significance for the resulting hits. In the classical approach one asks the question how probable...
Stefan Wolfsheimer, Inke Herms, Sven Rahmann, Alex...
BMCBI
2007
115views more  BMCBI 2007»
13 years 7 months ago
A novel, fast, HMM-with-Duration implementation - for application with a new, pattern recognition informed, nanopore detector
Background: Hidden Markov Models (HMMs) provide an excellent means for structure identification and feature extraction on stochastic sequential data. An HMM-with-Duration (HMMwD) ...
Stephen Winters-Hilt, Carl Baribault
BMCBI
2007
153views more  BMCBI 2007»
13 years 7 months ago
Analysis of nanopore detector measurements using Machine-Learning methods, with application to single-molecule kinetic analysis
Background: A nanopore detector has a nanometer-scale trans-membrane channel across which a potential difference is established, resulting in an ionic current through the channel ...
Matthew Landry, Stephen Winters-Hilt
BMCBI
2007
179views more  BMCBI 2007»
13 years 7 months ago
Automated smoother for the numerical decoupling of dynamics models
Background: Structure identification of dynamic models for complex biological systems is the cornerstone of their reverse engineering. Biochemical Systems Theory (BST) offers a pa...
Marco Vilela, Carlos Cristiano H. Borges, Susana V...
BMCBI
2007
98views more  BMCBI 2007»
13 years 7 months ago
Duration learning for analysis of nanopore ionic current blockades
Background: Ionic current blockade signal processing, for use in nanopore detection, offers a promising new way to analyze single molecule properties, with potential implications ...
Alexander G. Churbanov, Carl Baribault, Stephen Wi...