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» Transcriptional regulation at a glance
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BMCBI
2008
126views more  BMCBI 2008»
13 years 9 months ago
GeneChaser: Identifying all biological and clinical conditions in which genes of interest are differentially expressed
Background: The amount of gene expression data in the public repositories, such as NCBI Gene Expression Omnibus (GEO) has grown exponentially, and provides a gold mine for bioinfo...
Rong Chen, Rohan Mallelwar, Ajit Thosar, Shivkumar...
BMCBI
2008
138views more  BMCBI 2008»
13 years 9 months ago
Comparative analyses of bidirectional promoters in vertebrates
Background: Orthologous genes with deep phylogenetic histories are likely to retain similar regulatory features. In this report we utilize orthology assignments for pairs of genes...
Mary Qu Yang, James Taylor, Laura Elnitski
BMCBI
2007
111views more  BMCBI 2007»
13 years 8 months ago
MotifCombinator: a web-based tool to search for combinations of cis-regulatory motifs
Background: A combination of multiple types of transcription factors and cis-regulatory elements is often required for gene expression in eukaryotes, and the combinatorial regulat...
Mamoru Kato, Tatsuhiko Tsunoda
BMCBI
2007
104views more  BMCBI 2007»
13 years 9 months ago
Identification of putative regulatory upstream ORFs in the yeast genome using heuristics and evolutionary conservation
Background: The translational efficiency of an mRNA can be modulated by upstream open reading frames (uORFs) present in certain genes. A uORF can attenuate translation of the main...
Marija Cvijovic, Daniel Dalevi, Elizabeth Bilsland...
BMCBI
2007
148views more  BMCBI 2007»
13 years 8 months ago
p53FamTaG: a database resource of human p53, p63 and p73 direct target genes combining in silico prediction and microarray data
Background: The p53 gene family consists of the three genes p53, p63 and p73, which have polyhedral non-overlapping functions in pivotal cellular processes such as DNA synthesis a...
Elisabetta Sbisà, Domenico Catalano, Giorgi...