p53FamTaG: a database resource of human p53, p63 and p73 direct target genes combining in silico prediction and microarray data

Background: The p53 gene family consists of the three genes p53, p63 and p73, which have polyhedral non-overlapping functions in pivotal cellular processes such as DNA synthesis and repair, growth arrest, apoptosis, genome stability, angiogenesis, development and differentiation. These genes encode sequence-specific nuclear transcription factors that recognise the same responsive element (RE) in their target genes. Their inactivation or aberrant expression may determine tumour progression or developmental disease. The discovery of several protein isoforms with antagonistic roles, which are produced by the expression of different promoters and alternative splicing, widened the complexity of the scenario of the transcriptional network of the p53 family members. Therefore, the identification of the genes transactivated by p53 family members is crucial to understand the specific role for each gene in cell cycle regulation. We have combined a genome-wide computational search of p53 family ...

• Type: Journal
• Year: 2007
• Where: BMCBI
• Authors: Elisabetta Sbisà, Domenico Catalano, Giorgio Grillo, Flavio Licciulli, Antonio Turi, Sabino Liuni, Graziano Pesole, Anna De Grassi, Mariano Francesco Caratozzolo, Anna Maria D'Erchia, Beatriz Navarro, Apollonia Tullo, Cecilia Saccone, Andreas Gisel
• Keywords: BMCBI 2007, P53 Family, P53 Family Members, Target Genes