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BMCBI
2005
100views more  BMCBI 2005»
13 years 7 months ago
EvDTree: structure-dependent substitution profiles based on decision tree classification of 3D environments
Background: Structure-dependent substitution matrices increase the accuracy of sequence alignments when the 3D structure of one sequence is known, and are successful e.g. in fold ...
Jean-Christophe Gelly, Laurent Chiche, Jér&...
BMCBI
2005
97views more  BMCBI 2005»
13 years 7 months ago
The yeast kinome displays scale free topology with functional hub clusters
Background: The availability of interaction databases provides an opportunity for researchers to utilize immense amounts of data exclusively in silico. Recently there has been an ...
Robin E. C. Lee, Lynn A. Megeney
BMCBI
2005
163views more  BMCBI 2005»
13 years 7 months ago
CoaSim: A flexible environment for simulating genetic data under coalescent models
Background: Coalescent simulations are playing a large role in interpreting large scale intraspecific sequence or polymorphism surveys and for planning and evaluating association ...
Thomas Mailund, Mikkel H. Schierup, Christian N. S...
BMCBI
2005
98views more  BMCBI 2005»
13 years 7 months ago
InterferenceAnalyzer: Tools for the analysis and simulation of multi-locus genetic data
Background: Good statistical models for analyzing and simulating multilocus recombination data exist but are not accessible to many biologists because their use requires reasonabl...
Lalitha Viswanath, Elizabeth A. Housworth
JCB
2007
198views more  JCB 2007»
13 years 7 months ago
Bayesian Hierarchical Model for Large-Scale Covariance Matrix Estimation
Many bioinformatics problems can implicitly depend on estimating large-scale covariance matrix. The traditional approaches tend to give rise to high variance and low accuracy esti...
Dongxiao Zhu, Alfred O. Hero III