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BMCBI
2010
105views more  BMCBI 2010»
13 years 8 months ago
Predicting phenotypic traits of prokaryotes from protein domain frequencies
Background: Establishing the relationship between an organism's genome sequence and its phenotype is a fundamental challenge that remains largely unsolved. Accurately predict...
Thomas Lingner, Stefanie Mühlhausen, Toni Gab...
BMCBI
2007
110views more  BMCBI 2007»
13 years 8 months ago
Analysis of feedback loops and robustness in network evolution based on Boolean models
Background: Many biological networks such as protein-protein interaction networks, signaling networks, and metabolic networks have topological characteristics of a scale-free degr...
Yung-Keun Kwon, Kwang-Hyun Cho
BMCBI
2007
107views more  BMCBI 2007»
13 years 8 months ago
Reuse of structural domain-domain interactions in protein networks
Background: Protein interactions are thought to be largely mediated by interactions between structural domains. Databases such as iPfam relate interactions in protein structures t...
Benjamin Schuster-Böckler, Alex Bateman
CORR
2010
Springer
82views Education» more  CORR 2010»
13 years 8 months ago
Expansion and Search in Networks
Borrowing from concepts in expander graphs, we study the expansion properties of real-world, complex networks (e.g. social networks, unstructured peer-to-peer or P2P networks) and...
Arun S. Maiya, Tanya Y. Berger-Wolf
BMCBI
2006
144views more  BMCBI 2006»
13 years 8 months ago
Development and implementation of an algorithm for detection of protein complexes in large interaction networks
Background: After complete sequencing of a number of genomes the focus has now turned to proteomics. Advanced proteomics technologies such as two-hybrid assay, mass spectrometry e...
Md. Altaf-Ul-Amin, Yoko Shinbo, Kenji Mihara, Ken ...