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BMCBI
2010
110views more  BMCBI 2010»
13 years 7 months ago
Discovering local patterns of co - evolution: computational aspects and biological examples
Background: Co-evolution is the process in which two (or more) sets of orthologs exhibit a similar or correlative pattern of evolution. Co-evolution is a powerful way to learn abo...
Tamir Tuller, Yifat Felder, Martin Kupiec
BMCBI
2008
158views more  BMCBI 2008»
13 years 7 months ago
Bioinformatics in Italy: BITS2007, the fourth annual meeting of the Italian Society of Bioinformatics
spectives. A total of 149 abstracts were accepted and presented in the poster session and 31 of them were selected for oral presentation. At the opening of the meeting, Roderic Gui...
Graziano Pesole, Manuela Helmer-Citterich
BMCBI
2007
148views more  BMCBI 2007»
13 years 7 months ago
fREDUCE: Detection of degenerate regulatory elements using correlation with expression
Background: The precision of transcriptional regulation is made possible by the specificity of physical interactions between transcription factors and their cognate binding sites ...
Randy Z. Wu, Christina Chaivorapol, Jiashun Zheng,...
BMCBI
2010
119views more  BMCBI 2010»
13 years 7 months ago
Multi-task learning for cross-platform siRNA efficacy prediction: an in-silico study
Background: Gene silencing using exogenous small interfering RNAs (siRNAs) is now a widespread molecular tool for gene functional study and new-drug target identification. The key...
Qi Liu, Qian Xu, Vincent Wenchen Zheng, Hong Xue, ...
BMCBI
2007
94views more  BMCBI 2007»
13 years 7 months ago
A structural analysis of in vitro catalytic activities of hammerhead ribozymes
Background: Ribozymes are small catalytic RNAs that possess the dual functions of sequencespecific RNA recognition and site-specific cleavage. Trans-cleaving ribozymes can inhibit...
Yu Shao, Susan Wu, Chi Yu Chan, Jessie R. Klapper,...