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BMCBI
2010
133views more  BMCBI 2010»
13 years 7 months ago
Predicting enzyme targets for cancer drugs by profiling human Metabolic reactions in NCI-60 cell lines
Background: Drugs can influence the whole metabolic system by targeting enzymes which catalyze metabolic reactions. The existence of interactions between drugs and metabolic react...
Limin Li, Xiaobo Zhou, Wai-Ki Ching, Ping Wang
SIGMETRICS
2004
ACM
118views Hardware» more  SIGMETRICS 2004»
14 years 1 months ago
A game theoretic approach to provide incentive and service differentiation in P2P networks
Traditional Peer-to-Peer (P2P) networks do not provide service differentiation and incentive for users. Consequently, users can easily access information without contributing any ...
Richard T. B. Ma, Sam C. M. Lee, John C. S. Lui, D...
BMCBI
2010
214views more  BMCBI 2010»
13 years 7 months ago
AutoSOME: a clustering method for identifying gene expression modules without prior knowledge of cluster number
Background: Clustering the information content of large high-dimensional gene expression datasets has widespread application in "omics" biology. Unfortunately, the under...
Aaron M. Newman, James B. Cooper
BMCBI
2008
155views more  BMCBI 2008»
13 years 7 months ago
ComPath: comparative enzyme analysis and annotation in pathway/subsystem contexts
Background: Once a new genome is sequenced, one of the important questions is to determine the presence and absence of biological pathways. Analysis of biological pathways in a ge...
Kwangmin Choi, Sun Kim
BMCBI
2007
103views more  BMCBI 2007»
13 years 7 months ago
Dynamic simulation of regulatory networks using SQUAD
Background: The ambition of most molecular biologists is the understanding of the intricate network of molecular interactions that control biological systems. As scientists uncove...
Alessandro Di Cara, Abhishek Garg, Giovanni De Mic...