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    BMCBI
    2008
    105views more  BMCBI 2008»
    Using the longest significance run to estimate region-specific p-values in genetic association mapping studies
    13 years 9 months ago
    Using the longest significance run to estimate region-specific p-values in genetic association mapping studies
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    Background: Association testing is a powerful tool for identifying disease susceptibility genes underlying complex diseases. Technological advances have yielded a dramatic increas...
    Ie-Bin Lian, Yi-Hsien Lin, Ying-Chao Lin, Hsin-Cho...
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    BMCBI
    2007
    146views more  BMCBI 2007»
    Bayesian hierarchical model for transcriptional module discovery by jointly modeling gene expression and ChIP-chip data
    13 years 9 months ago
    Bayesian hierarchical model for transcriptional module discovery by jointly modeling gene expression and ChIP-chip data
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    Background: Transcriptional modules (TM) consist of groups of co-regulated genes and transcription factors (TF) regulating their expression. Two high-throughput (HT) experimental ...
    Xiangdong Liu, Walter J. Jessen, Siva Sivaganesan,...
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    BMCBI
    2007
    123views more  BMCBI 2007»
    PedGenie: meta genetic association testing in mixed family and case-control designs
    13 years 9 months ago
    PedGenie: meta genetic association testing in mixed family and case-control designs
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    Background-: PedGenie software, introduced in 2006, includes genetic association testing of cases and controls that may be independent or related (nuclear families or extended ped...
    Karen Curtin, Jathine Wong, Kristina Allen-Brady, ...
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    BMCBI
    2008
    107views more  BMCBI 2008»
    Multi-agent systems in epidemiology: a first step for computational biology in the study of vector-borne disease transmission
    13 years 9 months ago
    Multi-agent systems in epidemiology: a first step for computational biology in the study of vector-borne disease transmission
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    Background: Computational biology is often associated with genetic or genomic studies only. However, thanks to the increase of computational resources, computational models are ap...
    Benjamin Roche, Jean-François Guégan...
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    BMCBI
    2008
    155views more  BMCBI 2008»
    Extending pathways based on gene lists using InterPro domain signatures
    13 years 9 months ago
    Extending pathways based on gene lists using InterPro domain signatures
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    Background: High-throughput technologies like functional screens and gene expression analysis produce extended lists of candidate genes. Gene-Set Enrichment Analysis is a commonly...
    Florian Hahne, Alexander Mehrle, Dorit Arlt, Annem...
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