PedGenie: meta genetic association testing in mixed family and case-control designs

Background-: PedGenie software, introduced in 2006, includes genetic association testing of cases and controls that may be independent or related (nuclear families or extended pedigrees) or mixtures thereof using Monte Carlo significance testing. Our aim is to demonstrate that PedGenie, a unique and flexible analysis tool freely available in Genie 2.4 software, is significantly enhanced by incorporating meta statistics for detecting genetic association with disease using data across multiple study groups. Methods-: Meta statistics (chi-squared tests, odds ratios, and confidence intervals) were calculated using formal Cochran-Mantel-Haenszel techniques. Simulated data from unrelated individuals and individuals in families were used to illustrate meta tests and their empirically-derived p-values and confidence intervals are accurate, precise, and for independent designs match those provided by standard statistical software. Results-: PedGenie yields accurate Monte Carlo p-values for met...

• Type: Journal
• Year: 2007
• Where: BMCBI
• Authors: Karen Curtin, Jathine Wong, Kristina Allen-Brady, Nicola J. Camp
• Keywords: BMCBI 2007, Confidence Intervals, Meta, Meta Statistics