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JCB
2006
185views more  JCB 2006»
13 years 8 months ago
A Probabilistic Methodology for Integrating Knowledge and Experiments on Biological Networks
Biological systems are traditionally studied by focusing on a specific subsystem, building an intuitive model for it, and refining the model using results from carefully designed ...
Irit Gat-Viks, Amos Tanay, Daniela Raijman, Ron Sh...
BMCBI
2006
129views more  BMCBI 2006»
13 years 8 months ago
Functional clustering of yeast proteins from the protein-protein interaction network
Background: The abundant data available for protein interaction networks have not yet been fully understood. New types of analyses are needed to reveal organizational principles o...
Taner Z. Sen, Andrzej Kloczkowski, Robert L. Jerni...
BMCBI
2007
124views more  BMCBI 2007»
13 years 8 months ago
A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality
Background: Identifying all protein complexes in an organism is a major goal of systems biology. In the past 18 months, the results of two genome-scale tandem affinity purificatio...
G. Traver Hart, Insuk Lee, Edward M. Marcotte
BMCBI
2008
138views more  BMCBI 2008»
13 years 8 months ago
Systematic identification of yeast cell cycle transcription factors using multiple data sources
Background: Eukaryotic cell cycle is a complex process and is precisely regulated at many levels. Many genes specific to the cell cycle are regulated transcriptionally and are exp...
Wei-Sheng Wu, Wen-Hsiung Li
BMCBI
2006
122views more  BMCBI 2006»
13 years 8 months ago
Computational reconstruction of transcriptional regulatory modules of the yeast cell cycle
Background: A transcriptional regulatory module (TRM) is a set of genes that is regulated by a common set of transcription factors (TFs). By organizing the genome into TRMs, a liv...
Wei-Sheng Wu, Wen-Hsiung Li, Bor-Sen Chen