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BMCBI
2007
94views more  BMCBI 2007»
13 years 8 months ago
Model based analysis of real-time PCR data from DNA binding dye protocols
Background: Reverse transcription followed by real-time PCR is widely used for quantification of specific mRNA, and with the use of double-stranded DNA binding dyes it is becoming...
Mariano J. Alvarez, Guillermo J. Vila-Ortiz, Maria...
BMCBI
2005
103views more  BMCBI 2005»
13 years 8 months ago
SeqDoC: rapid SNP and mutation detection by direct comparison of DNA sequence chromatograms
Background: This paper describes SeqDoC, a simple, web-based tool to carry out direct comparison of ABI sequence chromatograms. This allows the rapid identification of single nucl...
Mark L. Crowe
BMCBI
2005
113views more  BMCBI 2005»
13 years 8 months ago
Normal uniform mixture differential gene expression detection for cDNA microarrays
Background: One of the primary tasks in analysing gene expression data is finding genes that are differentially expressed in different samples. Multiple testing issues due to the ...
Nema Dean, Adrian E. Raftery
BMCBI
2004
127views more  BMCBI 2004»
13 years 8 months ago
Optimized LOWESS normalization parameter selection for DNA microarray data
Background: Microarray data normalization is an important step for obtaining data that are reliable and usable for subsequent analysis. One of the most commonly utilized normaliza...
John A. Berger, Sampsa Hautaniemi, Anna-Kaarina J&...
BMCBI
2002
109views more  BMCBI 2002»
13 years 8 months ago
Kangaroo - A pattern-matching program for biological sequences
Background: Biologists are often interested in performing a simple database search to identify proteins or genes that contain a well-defined sequence pattern. Many databases do no...
Doron Betel, Christopher W. V. Hogue