The coiled-coil protein domain is a widespread structural motif known to be involved in a wealth of key interactions in cells and organisms. Coiled-coil recognition and prediction ...
—High-throughput data such as microarrays make it possible to investigate the molecular-level mechanism of cancer more efficiently. Computational methods boost the microarray ana...
Chan-Hoon Park, Soo-Jin Kim, Sun Kim, Dong-Yeon Ch...
Discovering human disease-causing genes (disease genes in short) is one of the most challenging problems in bioinformatics and biomedicine, as most diseases are related in some wa...
Prediction of gene functions is a major challenge to biologists in the post-genomic era. Interactions between genes and their products compose networks and can be used to infer ge...
Clustering has been shown to be effective in analyzing functional relationships of genes. However, no single clustering method with single distance metric is capable of capturing ...
Fatih Altiparmak, Selnur Erdal, Ozgur Ozturk, Haka...
An important problem in high-throughput protein crystallography is constructing a protein model from an electron-density map. Previous work by some of this paper’s authors [1] d...
Frank DiMaio, Ameet Soni, George N. Phillips, Jude...
Thousands of biochemical interactions are available for download from curated databases such as Reactome, Pathway Interaction Database and other sources in the Biological Pathways...
Oliver Ruebenacker, Ion I. Moraru, James C. Schaff...
With the wide application of green fluorescent protein (GFP) in the study of live cells, there is a surging need for the computer-aided analysis on the huge amount of image seque...
DNA microarrays have demonstrated an excellent potential in correlating specific gene expression profiles to specific conditions. However, they are affected by inherent noise. ...