BMCBI
2004
13 years 11 months ago
2004
Background: The family of voltage-gated potassium channels comprises a functionally diverse group of membrane proteins. They help maintain and regulate the potassium ion-based com...
BMCBI
2004
13 years 11 months ago
2004
Background: Microarray data normalization is an important step for obtaining data that are reliable and usable for subsequent analysis. One of the most commonly utilized normaliza...
BMCBI
2004
13 years 11 months ago
2004
Background: Microarray-based comparative genome hybridization experiments generate data that can be mapped onto the genome. These data are interpreted more easily when represented...
BMCBI
2004
13 years 11 months ago
2004
Background: With ever increasing numbers of closely related virus genomes being sequenced, it has become desirable to be able to compare two genomes at a level more detailed than ...
BMCBI
2004
13 years 11 months ago
2004
Background: Thousands of genes in a genomewide data set are tested against some null hypothesis, for detecting differentially expressed genes in microarray experiments. The expect...
BMCBI
2004
13 years 11 months ago
2004
Background: Microarray technologies produced large amount of data. The hierarchical clustering is commonly used to identify clusters of co-expressed genes. However, microarray dat...
BMCBI
2004
13 years 11 months ago
2004
Background: A major goal of cancer research is to identify discrete biomarkers that specifically characterize a given malignancy. These markers are useful in diagnosis, may identi...
BMCBI
2004
13 years 11 months ago
2004
Background: Ranked gene lists from microarray experiments are usually analysed by assigning significance to predefined gene categories, e.g., based on functional annotations. Tool...
BMCBI
2004
13 years 11 months ago
2004
Background: The usefulness of log2 transformation for cDNA microarray data has led to its widespread application to Affymetrix data. For Affymetrix data, where absolute intensitie...
BMCBI
2004
13 years 11 months ago
2004
Background: One of the most time-consuming tasks after performing a gene expression experiment is the biological interpretation of the results by identifying physiologically impor...