BMCBI
2005
13 years 11 months ago
2005
Background: MicroRNAs (miRNAs) are endogenous 21 to 23-nucleotide RNA molecules that regulate protein-coding gene expression in plants and animals via the RNA interference pathway...
BMCBI
2005
13 years 11 months ago
2005
Background: A number of algorithms for steady state analysis of metabolic networks have been developed over the years. Of these, Elementary Mode Analysis (EMA) has proven especial...
BMCBI
2005
13 years 11 months ago
2005
Background: CGH-Profiler is a program that supports the analysis of genomic aberrations measured by Comparative Genomic Hybridisation (CGH). Comparative genomic hybridisation (CGH...
BMCBI
2005
13 years 11 months ago
2005
Background: Codon substitution probabilities are used in many types of molecular evolution studies such as determining Ka/Ks ratios, creating ancestral DNA sequences or aligning c...
BMCBI
2005
13 years 11 months ago
2005
Background: Massive text mining of the biological literature holds great promise of relating disparate information and discovering new knowledge. However, disambiguation of gene s...
BMCBI
2005
13 years 11 months ago
2005
Background: The 'lid' subcomplex of the 26S proteasome and the COP9 signalosome (CSN complex) share a common architecture consisting of six subunits harbouring a so-call...
BMCBI
2005
13 years 11 months ago
2005
Background: Protein subcellular localization is an important determinant of protein function and hence, reliable methods for prediction of localization are needed. A number of pre...
BMCBI
2005
13 years 11 months ago
2005
Background: High-throughput genomic research tools are becoming standard in the biologist's toolbox. After processing the genomic data with one of the many available statisti...
BMCBI
2005
13 years 11 months ago
2005
Background: Many classification approaches have been applied to analyzing transcriptional regulation of gene expressions. These methods build models that can explain a gene's...
BMCBI
2005
13 years 11 months ago
2005
Background: Enhancements in sequencing technology have recently yielded assemblies of large genomes including rat, mouse, human, fruit fly, and zebrafish. The availability of larg...