BMCBI
2005
13 years 7 months ago
2005
Background: MicroRNAs (miRNAs) are endogenous 21 to 23-nucleotide RNA molecules that regulate protein-coding gene expression in plants and animals via the RNA interference pathway...
BMCBI
2005
13 years 7 months ago
2005
Background: A number of algorithms for steady state analysis of metabolic networks have been developed over the years. Of these, Elementary Mode Analysis (EMA) has proven especial...
BMCBI
2005
13 years 7 months ago
2005
Background: CGH-Profiler is a program that supports the analysis of genomic aberrations measured by Comparative Genomic Hybridisation (CGH). Comparative genomic hybridisation (CGH...
BMCBI
2005
13 years 7 months ago
2005
Background: Codon substitution probabilities are used in many types of molecular evolution studies such as determining Ka/Ks ratios, creating ancestral DNA sequences or aligning c...
BMCBI
2005
13 years 7 months ago
2005
Background: Massive text mining of the biological literature holds great promise of relating disparate information and discovering new knowledge. However, disambiguation of gene s...
BMCBI
2005
13 years 7 months ago
2005
Background: The 'lid' subcomplex of the 26S proteasome and the COP9 signalosome (CSN complex) share a common architecture consisting of six subunits harbouring a so-call...
BMCBI
2005
13 years 7 months ago
2005
Background: Protein subcellular localization is an important determinant of protein function and hence, reliable methods for prediction of localization are needed. A number of pre...
BMCBI
2005
13 years 7 months ago
2005
Background: High-throughput genomic research tools are becoming standard in the biologist's toolbox. After processing the genomic data with one of the many available statisti...
BMCBI
2005
13 years 7 months ago
2005
Background: Many classification approaches have been applied to analyzing transcriptional regulation of gene expressions. These methods build models that can explain a gene's...
BMCBI
2005
13 years 7 months ago
2005
Background: Enhancements in sequencing technology have recently yielded assemblies of large genomes including rat, mouse, human, fruit fly, and zebrafish. The availability of larg...