Here we identify duplicated genes in five mammalian genomes and classify these duplicates based on the mechanisms by which they were generated. Retrotransposition accounts for at l...
Paul Ryvkin, Jin Jun, Edward Hemphill, Craig Nelso...
The development of high-resolution microscopy makes possible the high-throughput screening of cellular information, such as gene expression at single cell resolution. One of the cr...
Fuhui Long, Hanchuan Peng, Xiao Liu, Stuart K. Kim...
We developed Gr?mlin 2.0, a new multiple network aligner with (1) a novel scoring function that can use arbitrary features of a multiple network alignment, such as protein deletion...
Jason Flannick, Antal F. Novak, Chuong B. Do, Bala...
Abstract. This paper presents an algorithm to detect lateral gene transfer (LGT) on the basis of pairwise evolutionary distances. The prediction is made from a likelihood ratio der...
Christophe Dessimoz, Daniel Margadant, Gaston H. G...
Understanding the variation of recombination rates across a given genome is crucial for disease gene mapping and for detecting signatures of selection, to name just a couple of app...
Abstract. While nonribosomal peptides (NRPs) are of tremendous pharmacological importance, there is currently no technology capable of highthroughput sequencing of NRPs. Difficulti...
Nuno Bandeira, Julio Ng, Dario Meluzzi, Roger G. L...
We report on a new algorithm for combining the information from several mass spectra of the same peptide. The algorithm automatically learns peptide fragmentation patterns, so that...
The protein inference problem represents a major challenge in shotgun proteomics. Here we describe a novel Bayesian approach to address this challenge that incorporates the predict...
Yong Fuga Li, Randy J. Arnold, Yixue Li, Predrag R...
Protein interactions and complexes are major components of biological systems. Recent genome-wide applications of tandem affinity purification (TAP) in yeast have increased signifi...
Comparative analysis of protein networks has proven to be a powerful approach for elucidating network structure and predicting protein function and interaction. A fundamental chall...