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CSB
2003
IEEE
135views Bioinformatics» more  CSB 2003»
14 years 4 months ago
Stepping Up the Pace of Discovery: the Genomes to Life Program
Genomes to Life (GTL), the U.S. Department of Energy Office of Science’s systems biology program, focuses on environmental microbiology. Over the next 10 to 20 years, GTL’s ke...
Marvin Frazier, David Thomassen, Aristides Patrino...
CSB
2003
IEEE
116views Bioinformatics» more  CSB 2003»
14 years 4 months ago
Towards Index-based Similarity Search for Protein Structure Databases
We propose two methods for finding similarities in protein structure databases. Our techniques extract feature vectors on triplets of SSEs (Secondary Structure Elements) of prote...
Orhan Çamoglu, Tamer Kahveci, Ambuj K. Sing...
CSB
2003
IEEE
121views Bioinformatics» more  CSB 2003»
14 years 4 months ago
Epitope Prediction Algorithms for Peptide based Vaccine Design
Peptide-based vaccines, in which small peptides derived from target proteins (epitopes) are used to provoke an immune reaction, have attracted considerable attention recently as a...
Liliana Florea, Bjarni V. Halldórsson, Oliv...
CSB
2003
IEEE
14 years 4 months ago
A Query Language to Support Scientific Discovery
Barbara A. Eckman, Kerry Deutsch, Marta Janer, Zo&...
CSB
2003
IEEE
152views Bioinformatics» more  CSB 2003»
14 years 4 months ago
A Parallel Genetic Algorithm for Physical Mapping of Chromosomes
Physical map reconstruction in the presence of errors is a central problem in genetics of high computational complexity. A parallel genetic algorithm for a maximum likelihood esti...
Suchendra M. Bhandarkar, Jinling Huang, Jonathan A...
CSB
2003
IEEE
101views Bioinformatics» more  CSB 2003»
14 years 4 months ago
Stochastic Stage-structured Modeling of the Adaptive Immune System
We have constructed a computer model of the cytotoxic T lymphocyte (CTL) response to antigen and the maintenance of immunological memory. Because immune responses often begin with...
Dennis L. Chao, Miles P. Davenport, Stephanie Forr...
CSB
2003
IEEE
130views Bioinformatics» more  CSB 2003»
14 years 4 months ago
A Computational Approach to Reconstructing Gene Regulatory Networks
Reverse-engineering of gene networks using linear models often results in an underdetermined system because of excessive unknown parameters. In addition, the practical utility of ...
Xutao Deng, Hesham H. Ali