BMCBI
2008
13 years 11 months ago
2008
Background: The analysis of gene sets has become a popular topic in recent times, with researchers attempting to improve the interpretability and reproducibility of their microarr...
BMCBI
2008
13 years 11 months ago
2008
Background: Health and disease of organisms are reflected in their phenotypes. Often, a genetic component to a disease is discovered only after clearly defining its phenotype. In ...
BMCBI
2008
13 years 11 months ago
2008
Background: High throughput microarray technologies have afforded the investigation of genomes, epigenomes, and transcriptomes at unprecedented resolution. However, software packa...
BMCBI
2008
13 years 11 months ago
2008
Background: A biomedical entity mention in articles and other free texts is often ambiguous. For example, 13% of the gene names (aliases) might refer to more than one gene. The ta...
BMCBI
2008
13 years 11 months ago
2008
Background: Genes interact with each other as basic building blocks of life, forming a complicated network. The relationship between groups of genes with different functions can b...
BMCBI
2007
13 years 11 months ago
2007
Background: In many laboratory-based high throughput microarray experiments, there are very few replicates of gene expression levels. Thus, estimates of gene variances are inaccur...
BMCBI
2008
13 years 11 months ago
2008
Background: The conservation of gene order among prokaryotic genomes can provide valuable insight into gene function, protein interactions, or events by which genomes have evolved...
BMCBI
2008
13 years 11 months ago
2008
Motivation: In the last years more than 20 vertebrate genomes have been sequenced, and the rate at which genomic DNA information becomes available is rapidly accelerating. Gene du...
BMCBI
2008
13 years 11 months ago
2008
Background: Microarray experiments measure changes in the expression of thousands of genes. The resulting lists of genes with changes in expression are then searched for biologica...
BMCBI
2008
13 years 11 months ago
2008
Background: Most gene finders score candidate gene models with state-based methods, typically HMMs, by combining local properties (coding potential, splice donor and acceptor patt...