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BMCBI
2010
164views more  BMCBI 2010»
13 years 11 months ago
Gene regulatory networks modelling using a dynamic evolutionary hybrid
Background: Inference of gene regulatory networks is a key goal in the quest for understanding fundamental cellular processes and revealing underlying relations among genes. With ...
Ioannis A. Maraziotis, Andrei Dragomir, Dimitris T...
BIBE
2010
IEEE
135views Bioinformatics» more  BIBE 2010»
13 years 11 months ago
Finding Dynamic Modules of Biological Regulatory Networks
—Often groups of genes in regulatory networks, also called modules, work collaboratively on similar functions. Mathematically, the modules in a regulatory network has often been ...
Ferhat Ay, Thang N. Dinh, My T. Thai, Tamer Kahvec...
BIOCOMP
2006
14 years 7 days ago
Dynamic Bayesian Network (DBN) with Structure Expectation Maximization (SEM) for Modeling of Gene Network from Time Series Gene
Exploring gene regulatory network is a key topic in molecular biology. In this paper, we present a new dynamic Bayesian network (DBN) framework embedded with structural expectatio...
Yu Zhang, Zhidong Deng, Hongshan Jiang, Peifa Jia
GECCO
2006
Springer
165views Optimization» more  GECCO 2006»
14 years 2 months ago
Comparing mathematical models on the problem of network inference
In this paper we address the problem of finding gene regulatory networks from experimental DNA microarray data. We focus on the evaluation of the performance of different mathemat...
Christian Spieth, Nadine Hassis, Felix Streichert
CMSB
2006
Springer
14 years 2 months ago
Regulatory Network Reconstruction Using Stochastic Logical Networks
Abstract. This paper presents a method for regulatory network reconstruction from experimental data. We propose a mathematical model for regulatory interactions, based on the work ...
Bartek Wilczynski, Jerzy Tiuryn
CSB
2003
IEEE
130views Bioinformatics» more  CSB 2003»
14 years 4 months ago
A Computational Approach to Reconstructing Gene Regulatory Networks
Reverse-engineering of gene networks using linear models often results in an underdetermined system because of excessive unknown parameters. In addition, the practical utility of ...
Xutao Deng, Hesham H. Ali
IDEAL
2004
Springer
14 years 4 months ago
Building Genetic Networks for Gene Expression Patterns
Building genetic regulatory networks from time series data of gene expression patterns is an important topic in bioinformatics. Probabilistic Boolean networks (PBNs) have been deve...
Wai-Ki Ching, Eric S. Fung, Michael K. Ng
RECOMB
2005
Springer
14 years 4 months ago
An Interactive Map of Regulatory Networks of Pseudomonas aeruginosa Genome
For studying gene regulatory and protein signaling networks, we have developed an interactive map for the Pseudomonas aeruginosa genome. We first represent genes, proteins and the...
Weihui Wu, Yongling Song, Shouguang Jin, Su-Shing ...
GECCO
2007
Springer
131views Optimization» more  GECCO 2007»
14 years 5 months ago
Using feedback to regulate gene expression in a developmental control architecture
We present what we believe is the first attempt to physically reconstruct the exploratory mechanism of genetic regulatory networks. Feedback plays a crucial role during developme...
Kester Clegg, Susan Stepney, Tim Clarke
BMEI
2008
IEEE
14 years 5 months ago
Using Phylogenetic Relationships to Improve the Inference of Transcriptional Regulatory Networks
Inferring transcriptional regulatory networks from geneexpression data remains a challenging problem, in part because of the noisy nature of the data and the lack of strong networ...
Xiuwei Zhang, Maryam Zaheri, Bernard M. E. Moret