Massively parallel sequencing technologies continue to alter the study of human genetics. As the cost of sequencing declines, next-generation sequencing (NGS) instruments and data...
Daniel C. Koboldt, Li Ding, Elaine R. Mardis, Rich...
Abstract. Applied Biosystems’ SOLiD system offers a low-cost alternative to the traditional Sanger method of DNA sequencing. We introduce two main algorithms of mapping SOLiD’...
Background: The advent of pyrophosphate sequencing makes large volumes of sequencing data available at a lower cost than previously possible. However, the short read lengths are d...
The car sequencing problem consists in sequencing a given set of cars to be produced in a single day. We address one of the variants of this problem, in which the objective of mini...
Celso C. Ribeiro, Daniel Aloise, Thiago F. Noronha...
Background: Recent technological advancements have made high throughput sequencing an increasingly popular approach for transcriptome analysis. Advantages of sequencing-based tran...
Zhijin Wu, Bethany D. Jenkins, Tatiana A. Rynearso...
Background: Determination of genetic relatedness among microorganisms provides information necessary for making inferences regarding phylogeny. However, there is little informatio...
Shotgun sequencing is the most widely used technique for determining the DNA sequence of organisms. It involves breaking up the DNA into many small pieces that can be read by auto...
Testing complex manufacturing systems, such as an ASML [1] lithographic machine, takes up to 45% of the total development time of a system. The problem of which tests must be execu...
R. Boumen, I. S. M. de Jong, J. W. H. Vermunt, J. ...
Background: The degree to which conventional DNA sequencing techniques will be successful for highly repetitive genomes is unclear. Investigators are therefore considering various...
Background: Determination and quantification of nucleic acid components in a mixture is usually accomplished by microarray approaches, where the mixtures are hybridized against sp...
Alexander E. Pozhitkov, Kathryn Stemshorn, Diethar...