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BMCBI
2007
89views more  BMCBI 2007»
13 years 11 months ago
msmsEval: tandem mass spectral quality assignment for high-throughput proteomics
Background: In proteomics experiments, database-search programs are the method of choice for protein identification from tandem mass spectra. As amino acid sequence databases grow...
Jason W. H. Wong, Matthew J. Sullivan, Hugh M. Car...
BMCBI
2010
124views more  BMCBI 2010»
13 years 11 months ago
A Dynamic Noise Level Algorithm for Spectral Screening of Peptide MS/MS Spectra
Background: High-throughput shotgun proteomics data contain a significant number of spectra from non-peptide ions or spectra of too poor quality to obtain highly confident peptide...
Hua Xu, Michael A. Freitas
BMCBI
2010
152views more  BMCBI 2010»
13 years 11 months ago
A high-throughput de novo sequencing approach for shotgun proteomics using high-resolution tandem mass spectrometry
Background: High-resolution tandem mass spectra can now be readily acquired with hybrid instruments, such as LTQ-Orbitrap and LTQ-FT, in high-throughput shotgun proteomics workflo...
Chongle Pan, Byung-Hoon Park, William H. McDonald,...
CSB
2005
IEEE
125views Bioinformatics» more  CSB 2005»
14 years 5 months ago
Peptide Charge State Determination for Low-Resolution Tandem Mass Spectra
Mass spectrometry is a particularly useful technology for the rapid and robust identification of peptides and proteins in complex mixtures. Peptide sequences can be identified b...
Aaron A. Klammer, Christine C. Wu, Michael J. MacC...
IMSCCS
2006
IEEE
14 years 5 months ago
Quality Assessment of Peptide Tandem Mass Spectra
Background: Tandem mass spectrometry has emerged as a cornerstone of high throughput proteomic studies owing in part to various high throughput search engines which are used to in...
Fang-Xiang Wu, Pierre Gagné, Arnaud Droit, ...
SIGIR
2009
ACM
14 years 6 months ago
Protein identification as an information retrieval problem
We present the first interdisciplinary work on transforming a popular problem in proteomics, i.e. protein identification from tandem mass spectra, to an Information Retrieval (IR)...
Yiming Yang, Subramaniam Ganapathy, Abhay Harpale