Two parties, say Alice and Bob, possess two sets of elements that belong to a universe of possible values and wish to test whether these sets are disjoint or not. In this paper we consider the above problem in the setting where Alice and Bob wish to disclose no information to each other about their sets beyond the single bit: “whether the intersection is empty or not.” This problem has many applications in commercial settings where two mutually distrustful parties wish to decide with minimum possible disclosure whether there is any overlap between their private datasets. We present three protocols that solve the above problem that meet different efficiency and security objectives and data representation scenarios. Our protocols are based on Homomorphic encryption and in our security analysis, we consider the semi-honest setting as well as the malicious setting. Our most efficient construction for a large universe in terms of overall communication complexity uses a new encryption p...