In this paper, after a new DNA-based semantic model is theoretically proposed, the preliminary experiment on construction of the small test model is successfully done. This model, referred to as ‘semantic model based on molecular computing’ (SMC) has the structure of a graph formed by the set of all (attribute, attribute values) pairs contained in the set of represented objects, plus a tag node for each object. Each path in the network, from an initial object-representing tag node to a terminal node represents the object named on the tag. Input of a set of input strands will result in the formation of object-representing dsDNAs via parallel self-assembly, from encoded ssDNAs representing both attributes and attribute values (nodes), as directed by ssDNA splinting strands representing relations (edges) in the network. The proposed model is rather suitable for knowledge representation in order to store vast amount of information with high density. The proposed model will appears as a...