The performance of a system, especially a multiprocessor system, heavily depends upon the efficiency of its bus architecture. This paper presents a methodology to generate a custom bus system for a multiprocessor System-on-a-Chip (SoC). Our bus synthesis tool (BusSyn) uses this methodology to generate five different bus systems as examples: Bi-FIFO Bus Architecture (BFBA), Global Bus Architecture Version I (GBAVI), Global Bus Architecture Version III (GBAVIII), Hybrid bus architecture (Hybrid) and Split Bus Architecture (SplitBA). We verify and evaluate the performance of each bus system in the context of two applications: an Orthogonal Frequency Division Multiplexing (OFDM) wireless transmitter and an MPEG2 decoder. This methodology gives the designer a great benefit in fast design space exploration of bus architectures across a variety of performance impacting factors such as bus types, processor types and software programming style. In this paper, we show that BusSyn can generate b...