- Integrating information about protein sequence and structure allows further exploration and establishment of protein sequence-structure-function relations. However, protein data integration faces challenges at technology level for interfacing heterogeneous data formats and at application level for semantic interpretation of dissimilar data and queries. In this paper, we investigate the application of semantic web services in making protein data resources (e.g., databases and web servers) more accessible with enhanced semantic discovery capability. First, data resources that provide protein information (or features) are modeled as web services. Then domain and upper ontologies are used to precisely describe the query capabilities of web services and the data requirements of service requests. Finally, an efficient matching algorithm is used to match service requests with services. Our experiments reveal that semantic discovery of protein resources can be achieved with reasonable perfor...
Xiong Liu, Hassan A. Karimi