DAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput

Background: Due to the complex and distributed nature of biological research, our current biological knowledge is spread over many redundant annotation databases maintained by many independent groups. Analysts usually need to visit many of these bioinformatics databases in order to integrate comprehensive annotation information for their genes, which becomes one of the bottlenecks, particularly for the analytic task associated with a large gene list. Thus, a highly centralized and ready-to-use gene-annotation knowledgebase is in demand for high throughput gene functional analysis. Description: The DAVID Knowledgebase is built around the DAVID Gene Concept, a single-linkage method to agglomerate tens of millions of gene/protein identifiers from a variety of public genomic resources into DAVID gene clusters. The grouping of such identifiers improves the cross-reference capability, particularly across NCBI and UniProt systems, enabling more than 40 publicly available functional annotatio...

• Type: Journal
• Year: 2007
• Where: BMCBI
• Authors: Brad T. Sherman, Da Wei Huang, Qina Tan, Yongjian Guo, Stephan Bour, David Liu, Robert M. Stephens, Michael W. Baseler, H. Clifford Lane, Richard A. Lempicki
• Keywords: BMCBI 2007, David Gene, DAVID Knowledgebase, Gene