Gene Prospector: An evidence gateway for evaluating potential susceptibility genes and interacting risk factors for human diseas

Background: Millions of single nucleotide polymorphisms have been identified as a result of the human genome project and the rapid advance of high throughput genotyping technology. Genetic association studies, such as recent genome-wide association studies (GWAS), have provided a springboard for exploring the contribution of inherited genetic variation and gene/environment interactions in relation to disease. Given the capacity of such studies to produce a plethora of information that may then be described in a number of publications, selecting possible disease susceptibility genes and identifying related modifiable risk factors is a major challenge. A Web-based application for finding evidence of such relationships is key to the development of follow-up studies and evidence for translational research. We developed a Web-based application that selects and prioritizes potential disease-related genes by using a highly curated and updated literature database of genetic association studie...

• Type: Journal
• Year: 2008
• Where: BMCBI
• Authors: Wei Yu, Anja Wulf, Tiebin Liu, Muin J. Khoury, Marta Gwinn
• Keywords: BMCBI 2008, Candidate Genes, Gene Prospector, Genetic Association Studies