Missing value estimation for DNA microarray gene expression data by Support Vector Regression imputation and orthogonal coding s

Background: Gene expression profiling has become a useful biological resource in recent years, and it plays an important role in a broad range of areas in biology. The raw gene expression data, usually in the form of large matrix, may contain missing values. The downstream analysis methods that postulate complete matrix input are thus not applicable. Several methods have been developed to solve this problem, such as K nearest neighbor impute method, Bayesian principal components analysis impute method, etc. In this paper, we introduce a novel imputing approach based on the Support Vector Regression (SVR) method. The proposed approach utilizes an orthogonal coding input scheme, which makes use of multi-missing values in one row of a certain gene expression profile and imputes the missing value into a much higher dimensional space, to obtain better performance. Results: A comparative study of our method with the previously developed methods has been presented for the estimation of the m...

• Type: Journal
• Year: 2006
• Where: BMCBI
• Authors: Xian Wang, Ao Li, Zhaohui Jiang, Huanqing Feng
• Keywords: BMCBI 2006, Gene Expression, Impute Method, Missing Value