The effects of multiple features of alternatively spliced exons on the KA/KS ratio test

Background: The evolution of alternatively spliced exons (ASEs) is of primary interest because these exons are suggested to be a major source of functional diversity of proteins. Many exon features have been suggested to affect the evolution of ASEs. However, previous studies have relied on the KA/KS ratio test without taking into consideration information sufficiency (i.e., exon length > 75 bp, cross-species divergence > 5%) of the studied exons, leading to potentially biased interpretations. Furthermore, which exon feature dominates the results of the KA/KS ratio test and whether multiple exon features have additive effects have remained unexplored. Results: In this study, we collect two different datasets for analysis

• Type: Journal
• Year: 2006
• Where: BMCBI
• Authors: Feng-Chi Chen, Trees-Juen Chuang
• Keywords: ASes, BMCBI 2006, Exon, Ratio Test