Gene analogue finder: a GRID solution for finding functionally analogous gene products

Background: To date more than 2,1 million gene products from more than 100000 different species have been described specifying their function, the processes they are involved in and their cellular localization using a very well defined and structured vocabulary, the gene ontology (GO). Such vast, well defined knowledge opens the possibility of compare gene products at the level of functionality, finding gene products which have a similar function or are involved in similar biological processes without relying on the conventional sequence similarity approach. Comparisons within such a large space of knowledge are highly data and computing intensive. For this reason this project was based upon the use of the computational GRID, a technology offering large computing and storage resources. Results: We have developed a tool, GENe AnaloGue FINdEr (ENGINE) that parallelizes the search process and distributes the calculation and data over the computational GRID, splitting the process into man...

• Type: Journal
• Year: 2007
• Where: BMCBI
• Authors: Angelica Tulipano, Giacinto Donvito, Flavio Licciulli, Giorgio Pietro Maggi, Andreas Gisel
• Keywords: BMCBI 2007, Computational Grid, Gene Products, Similar Functions