NOTUNG: A Program for Dating Gene Duplications and Optimizing Gene Family Trees

Large scale gene duplication is a major force driving the evolution of genetic functional innovation. Whole genome duplications are widely believed to have played an important role in the evolution of the maize, yeast and vertebrate genomes. The use of evolutionary trees to analyze the history of gene duplication and estimate duplication times provides a powerful tool for studying this process. Many studies in the molecular evolution literature have used this approach on small data sets, using analyses performed by hand. The rapid growth of genetic sequence data will soon allow similar studies on a genomic scale, but such studies will be limited unless the analysis can be automated. Even existing data sets admit alternative hypotheses that would be too tedious to consider without automation. In this paper, we describe a program called Notung that facilitates large scale analysis, using both rooted and unrooted trees. When tested on trees analyzed in the literature, Notung consistently...

• Type: Journal
• Year: 2000
• Where: JCB
• Authors: Kevin Chen, Dannie Durand, Martin Farach-Colton
• Keywords: Gene Duplication, JCB 2000, Large Scale, Scale Gene Duplication