Computational Consequences of Temporally Asymmetric Learning Rules: II. Sensory Image Cancellation

Abstract. The electrosensory lateral line lobe (ELL) of mormyridelectric sh is a cerebellum-likestructure that receives primarya erent input from electroreceptors in the skin. Purkinje-likecells in ELL store and retrieve a temporally precise negative image of prior sensory input. The stored image is derived from the association of centrally originating predictive signals with peripherally originating sensory input. The predictive signalsare probablyconveyedby parallel bers. Recent in vitroexperiments havedemonstrated that pairing parallel ber-evoked excitatory postsynaptic potentials (epsps) with postsynaptic spikes in Purkinje-like cells depresses the strength of these synapses. The depression has a tight dependence on the temporal order of pre- and postsynaptic events. The postsynaptic spike must follow the onset of the epsp within a window of about 60 msec for the depression to occur and pairings at other delays yield a non-associative enhancement of the epsp. Mathematical analyses ...

• Type: Journal
• Year: 2000
• Where: JCNS
• Authors: Patrick D. Roberts, Curtis C. Bell
• Keywords: JCNS 2000, Lateral Line Lobe, Postsynaptic Spike, Sensory Input