We investigate trade-offs in microprocessor frequency and system power achievable for low temperature operation in scaled high leakage technologies by combining refrigeration with supply voltage selection, body bias, transistor sizing and shorter channel length. Reducing channel length provides better frequency and power improvement than forward body bias. When, the leakage power is more than 30% of chip power, combining refrigeration with enhancing technology by shorter channel length provides the best trade-off for power and frequency. Categories & Subject Descriptors: Design General Terms: Design, Performance