Due to the shrinking of feature size and reduction in supply voltages, nanoscale circuits have become more susceptible to radiation induced transient faults. In this paper, we present a symbolic framework based on BDDs and ADDs that enables analysis of combinational circuit reliability from different aspects: output susceptibility to error, influence of individual gates on individual outputs and overall circuit reliability, and the dependence of circuit reliability on glitch duration, amplitude, and input patterns. This is demonstrated by the set of experimental results, which show that the mean output error susceptibility can vary from less than 0.1%, for large circuits and small glitches, to about 30% for very small circuits and large enough glitches. The results obtained with the proposed symbolic framework are within 7% average error and up to 5000X speedup when compared to HSPICE detailed circuit simulation. The framework can be used for selective gate sizing targeting radiation ...