—Energy becomes the primary concern in nowadays multi-core architecture designs. Moore’s law predicts that the exponentially increasing number of cores can be packed into a single chip every two years, however, the increasing power density is the obstacle to continuous performance gains. Recent studies show that heterogeneous multi-core is a competitive promising solution to optimize performance per watt. In this paper, different types of heterogeneous architecture are discussed. For each type, current challenges and latest solutions are briefly introduced. Preliminary analyses are performed to illustrate the scalability of the heterogeneous system and the potential benefits towards future application requirements. Moreover, we demonstrate the advantages of leveraging three-dimensional (3D) integration on heterogeneous architectures. With 3D die stacking, disparate technologies can be integrated on the same chip, such as the CMOS logic and emerging non-volatile memory, enabling a...