Implementing a custom hardware is not always feasible due to cost and time considerations. No instruction set computer (NISC) architecture is one of the promising direction to design a custom datapath for each application using its execution characteristics. A major challenge with NISC control word is that they tend to be at least 4 to 5 times larger than regular instruction size, thereby imposing higher memory requirement. A promising approach is to compress these control words to reduce the code size of the application. This article proposes an efficient bitmask-based compression technique to drastically reduce the control word size while keeping the decompression overhead minimal. The main contributions of our approach are: i) efficient don’t care resolution for maximum bitmask coverage using limited dictionary entries, ii) run length encoding to significantly reduce repetitive control words, and iii) smart encoding of constant and less frequently changing bits. Our experiment...