— Coupled oscillator networks occur in various domains such as biology, astrophysics and electronics. In this paper, we present a comprehensive procedure for rapid and accurate simulation of large coupled oscillator networks using widely accepted, fully-nonlinear Perturbation Projection Vector (PPV) phase macromodels. We validate our method against full simulation of 20x20 coupled network of Brusselator biochemical oscillator and obtain computational speedups of 170x over full simulation. Furthermore, we apply the method to study self-organization phenomenon of Brusselator under asymmetric coupling and time period variations.