Serious games and especially their use in healthcare applications are an active and rapidly growing area of research. A key aspect of games in rehabilitation is 3D input. In this paper we present our implementation of a full body motion capture (MoCap) system, which, together with a biosignal acquisition device, has been integrated in a game engine. Furthermore, a workflow has been established that enables the use of acquired skeletal data for serious games in a medical environment. Finally, a serious game has been implemented, targeting rehabilitation of patients with chronic pain of the lower back and neck, a group that has previously been neglected by serious games. The focus of this work is on the full body MoCap system and its integration with biosignal devices and the game engine. A short overview of the application and prelimiary results are provided. Categories and Subject Descriptors H.5.2 [Information Interfaces and Presentation]: User Interfaces—Input devices and strateg...