RepSeq - A database of amino acid repeats present in lower eukaryotic pathogens

Background: Amino acid repeat-containing proteins have a broad range of functions and their identification is of relevance to many experimental biologists. In human-infective protozoan parasites (such as the Kinetoplastid and Plasmodium species), they are implicated in immune evasion and have been shown to influence virulence and pathogenicity. RepSeq http://repseq.gugbe.com is a new database of amino acid repeat-containing proteins found in lower eukaryotic pathogens. The RepSeq database is accessed via a web-based application which also provides links to related online tools and databases for further analyses. Results: The RepSeq algorithm typically identifies more than 98% of repeat-containing proteins and is capable of identifying both perfect and mismatch repeats. The proportion of proteins that contain repeat elements varies greatly between different families and even species (3–35% of the total protein content). The most common motif type is the Sequence Repeat Region (SRR) â...

• Type: Journal
• Year: 2007
• Where: BMCBI
• Authors: Daniel P. Depledge, Ryan P. J. Lower, Deborah F. Smith
• Keywords: Amino Acid, BMCBI 2007, Lower Eukaryotic Pathogens, Proteins