As larger macromolecular structures become available, there is a growing need to understand their `internal' volumes--such as deep clefts, channels and cavities--as these oft...
Background: Comparing related structures and viewing the structures in the context of sequence alignments are important tasks in protein structure-function research. While many pr...
Elaine C. Meng, Eric F. Pettersen, Gregory S. Couc...
In this paper, we present CONTRAlign, an extensible and fully automatic framework for parameter learning and protein pairwise sequence alignment using pair conditional random field...
Evaluation of ontology alignments is in practice done in two ways: (1) assessing individual correspondences and (2) comparing the alignment to a reference alignment. However, this ...
Laura Hollink, Mark van Assem, Shenghui Wang, Anto...
Background: Profile-based analysis of multiple sequence alignments (MSA) allows for accurate comparison of protein families. Here, we address the problems of detecting statistical...