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BMCBI
2010
151views more  BMCBI 2010»
15 years 4 months ago
Using diffusion distances for flexible molecular shape comparison
Background: Many molecules are flexible and undergo significant shape deformation as part of their function, and yet most existing molecular shape comparison (MSC) methods treat t...
Yu-Shen Liu, Qi Li, Guo-Qin Zheng, Karthik Ramani,...
BMCBI
2008
115views more  BMCBI 2008»
15 years 4 months ago
Systems biology driven software design for the research enterprise
Background: In systems biology, and many other areas of research, there is a need for the interoperability of tools and data sources that were not originally designed to be integr...
John Boyle, Christopher C. Cavnor, Sarah A. Killco...
BMCBI
2007
120views more  BMCBI 2007»
15 years 4 months ago
Recognition of interferon-inducible sites, promoters, and enhancers
Background: Computational analysis of gene regulatory regions is important for prediction of functions of many uncharacterized genes. With this in mind, search of the target genes...
Elena A. Ananko, Yury V. Kondrakhin, Tatyana I. Me...
BMCBI
2007
109views more  BMCBI 2007»
15 years 4 months ago
Towards a comprehensive structural coverage of completed genomes: a structural genomics viewpoint
Background: Structural genomics initiatives were established with the aim of solving protein structures on a large-scale. For many initiatives, such as the Protein Structure Initi...
Russell L. Marsden, Tony A. Lewis, Christine A. Or...
BMCBI
2010
139views more  BMCBI 2010»
15 years 4 months ago
TOPSAN: a collaborative annotation environment for structural genomics
Background: Many protein structures determined in high-throughput structural genomics centers, despite their significant novelty and importance, are available only as PDB depositi...
Dana Weekes, S. Sri Krishna, Constantina Bakolitsa...