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» CONTRAlign: Discriminative Training for Protein Sequence Ali...
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RECOMB
2007
Springer
14 years 7 months ago
Support Vector Training of Protein Alignment Models
Abstract. Sequence to structure alignment is an important step in homology modeling of protein structures. Incorporation of features like secondary structure, solvent accessibility...
Chun-Nam John Yu, Thorsten Joachims, Ron Elber, Ja...
BMCBI
2010
104views more  BMCBI 2010»
13 years 6 months ago
A novel scoring function for discriminating hyperthermophilic and mesophilic proteins with application to predicting relative th
Background: The ability to design thermostable proteins is theoretically important and practically useful. Robust and accurate algorithms, however, remain elusive. One critical pr...
Yunqi Li, C. Russell Middaugh, Jianwen Fang
BMCBI
2006
101views more  BMCBI 2006»
13 years 6 months ago
Local protein structure prediction using discriminative models
Background: In recent years protein structure prediction methods using local structure information have shown promising improvements. The quality of new fold predictions has risen...
Oliver Sander, Ingolf Sommer, Thomas Lengauer
BMCBI
2007
93views more  BMCBI 2007»
13 years 6 months ago
SVM-Fold: a tool for discriminative multi-class protein fold and superfamily recognition
Background: Predicting a protein’s structural class from its amino acid sequence is a fundamental problem in computational biology. Much recent work has focused on developing ne...
Iain Melvin, Eugene Ie, Rui Kuang, Jason Weston, W...
BMCBI
2008
164views more  BMCBI 2008»
13 years 6 months ago
Word correlation matrices for protein sequence analysis and remote homology detection
Background: Classification of protein sequences is a central problem in computational biology. Currently, among computational methods discriminative kernel-based approaches provid...
Thomas Lingner, Peter Meinicke