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» Estimating dynamic models for gene regulation networks
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BMCBI
2007
144views more  BMCBI 2007»
13 years 7 months ago
Accelerated search for biomolecular network models to interpret high-throughput experimental data
Background: The functions of human cells are carried out by biomolecular networks, which include proteins, genes, and regulatory sites within DNA that encode and control protein e...
Suman Datta, Bahrad A. Sokhansanj
JCB
2006
114views more  JCB 2006»
13 years 7 months ago
A General Modeling Strategy for Gene Regulatory Networks with Stochastic Dynamics
A stochastic genetic toggle switch model that consists of two identical, mutually repressive genes is built using the Gillespie algorithm with time delays as an example of a simpl...
Andre Ribeiro, Rui Zhu, Stuart A. Kauffman
GECCO
2005
Springer
180views Optimization» more  GECCO 2005»
14 years 1 months ago
Inference of gene regulatory networks using s-system and differential evolution
In this work we present an improved evolutionary method for inferring S-system model of genetic networks from the time series data of gene expression. We employed Differential Ev...
Nasimul Noman, Hitoshi Iba
BMCBI
2004
135views more  BMCBI 2004»
13 years 7 months ago
Determination of the differentially expressed genes in microarray experiments using local FDR
Background: Thousands of genes in a genomewide data set are tested against some null hypothesis, for detecting differentially expressed genes in microarray experiments. The expect...
Julie Aubert, Avner Bar-Hen, Jean-Jacques Daudin, ...
EVOW
2007
Springer
14 years 1 months ago
Modeling the Shoot Apical Meristem in A. thaliana : Parameter Estimation for Spatial Pattern Formation
Understanding the self-regulatory mechanisms controlling the spatial and temporal structure of multicellular organisms represents one of the major challenges in molecular biology. ...
Tim Hohm, Eckart Zitzler