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BMCBI
2010
113views more  BMCBI 2010»
13 years 8 months ago
Unifying generative and discriminative learning principles
Background: The recognition of functional binding sites in genomic DNA remains one of the fundamental challenges of genome research. During the last decades, a plethora of differe...
Jens Keilwagen, Jan Grau, Stefan Posch, Marc Stric...
BMCBI
2004
146views more  BMCBI 2004»
13 years 8 months ago
Defining transcriptional networks through integrative modeling of mRNA expression and transcription factor binding data
Background: Functional genomics studies are yielding information about regulatory processes in the cell at an unprecedented scale. In the yeast S. cerevisiae, DNA microarrays have...
Feng Gao, Barrett C. Foat, Harmen J. Bussemaker
BMCBI
2007
148views more  BMCBI 2007»
13 years 8 months ago
fREDUCE: Detection of degenerate regulatory elements using correlation with expression
Background: The precision of transcriptional regulation is made possible by the specificity of physical interactions between transcription factors and their cognate binding sites ...
Randy Z. Wu, Christina Chaivorapol, Jiashun Zheng,...
RECOMB
2007
Springer
14 years 2 months ago
Nucleosome Occupancy Information Improves de novo Motif Discovery
A complete understanding of transcriptional regulatory processes in the cell requires identification of transcription factor binding sites on a genomewide scale. Unfortunately, th...
Leelavati Narlikar, Raluca Gordân, Alexander...
NAR
2010
107views more  NAR 2010»
13 years 3 months ago
FlyTF: improved annotation and enhanced functionality of the Drosophila transcription factor database
FlyTF (http://www.flytf.org) is a database of computationally predicted and/or experimentally verified site-specific transcription factors (TFs) in the fruit fly Drosophila melano...
Ulrike Pfreundt, Daniel P. James, Susan Tweedie, D...