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» Functional topology in a network of protein interactions
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BMCBI
2010
160views more  BMCBI 2010»
13 years 7 months ago
Identification of functional hubs and modules by converting interactome networks into hierarchical ordering of proteins
Background: Protein-protein interactions play a key role in biological processes of proteins within a cell. Recent high-throughput techniques have generated protein-protein intera...
Young-Rae Cho, Aidong Zhang
BMCBI
2005
97views more  BMCBI 2005»
13 years 7 months ago
The yeast kinome displays scale free topology with functional hub clusters
Background: The availability of interaction databases provides an opportunity for researchers to utilize immense amounts of data exclusively in silico. Recently there has been an ...
Robin E. C. Lee, Lynn A. Megeney
BMCBI
2007
90views more  BMCBI 2007»
13 years 7 months ago
Gene network interconnectedness and the generalized topological overlap measure
Background: Network methods are increasingly used to represent the interactions of genes and/ or proteins. Genes or proteins that are directly linked may have a similar biological...
Andy M. Yip, Steve Horvath
BMCBI
2008
78views more  BMCBI 2008»
13 years 7 months ago
Deducing topology of protein-protein interaction networks from experimentally measured sub-networks
Background: Protein-protein interaction networks are commonly sampled using yeast two hybrid approaches. However, whether topological information reaped from these experimentallym...
Ling Yang, Thomas M. Vondriska, Zhangang Han, W. R...
JBCB
2008
71views more  JBCB 2008»
13 years 7 months ago
Using Indirect protein-protein Interactions for protein Complex Prediction
Protein complexes are fundamental for understanding principles of cellular organizations. Accurate and fast protein complex prediction from the PPI networks of increasing sizes ca...
Hon Nian Chua, Kang Ning, Wing-Kin Sung, Hon Wai L...