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» Geometry of gene expression dynamics
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BIOINFORMATICS
2006
118views more  BIOINFORMATICS 2006»
13 years 7 months ago
A probabilistic dynamical model for quantitative inference of the regulatory mechanism of transcription
Motivation Quantitative estimation of the regulatory relationship between transcription factors and genes is a fundamental stepping stone when trying to develop models of cellular...
Guido Sanguinetti, Magnus Rattray, Neil D. Lawrenc...
BMCBI
2010
130views more  BMCBI 2010»
13 years 7 months ago
Analysis of DNA strand-specific differential expression with high density tiling microarrays
Background: DNA microarray technology allows the analysis of genome structure and dynamics at genome-wide scale. Expression microarrays (EMA) contain probes for annotated open rea...
Luis Quintales, Mar Sánchez, Francisco Ante...
BMCBI
2007
152views more  BMCBI 2007»
13 years 7 months ago
Difference-based clustering of short time-course microarray data with replicates
Background: There are some limitations associated with conventional clustering methods for short time-course gene expression data. The current algorithms require prior domain know...
Jihoon Kim, Ju Han Kim
BMCBI
2008
130views more  BMCBI 2008»
13 years 7 months ago
Function approximation approach to the inference of reduced NGnet models of genetic networks
Background: The inference of a genetic network is a problem in which mutual interactions among genes are deduced using time-series of gene expression patterns. While a number of m...
Shuhei Kimura, Katsuki Sonoda, Soichiro Yamane, Hi...
APBC
2004
116views Bioinformatics» more  APBC 2004»
13 years 9 months ago
Evolving Genetic Regulatory Networks Using an Artificial Genome
Boolean models of genetic regulatory networks (GRNs) have been shown to exhibit many of the characteristic dynamics of real GRNs, with gene expression patterns settling to point a...
Jennifer Hallinan, Janet Wiles