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» Reconstructing the pre-doubling genome
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BMCBI
2010
115views more  BMCBI 2010»
13 years 10 months ago
Machine learning methods for metabolic pathway prediction
Background: A key challenge in systems biology is the reconstruction of an organism's metabolic network from its genome sequence. One strategy for addressing this problem is ...
Joseph M. Dale, Liviu Popescu, Peter D. Karp
BMCBI
2007
160views more  BMCBI 2007»
13 years 10 months ago
Optimization based automated curation of metabolic reconstructions
Background: Currently, there exists tens of different microbial and eukaryotic metabolic reconstructions (e.g., Escherichia coli, Saccharomyces cerevisiae, Bacillus subtilis) with...
Vinay Satish Kumar, Madhukar S. Dasika, Costas D. ...
COCOON
2005
Springer
14 years 3 months ago
RIATA-HGT: A Fast and Accurate Heuristic for Reconstructing Horizontal Gene Transfer
Horizontal gene transfer (HGT) plays a major role in microbial genome diversiļ¬cation, and is claimed to be rampant among various groups of genes in bacteria. Further, HGT is a ma...
Luay Nakhleh, Derek A. Ruths, Li-San Wang
RECOMB
2004
Springer
14 years 10 months ago
The Distribution of Inversion Lengths in Bacteria
The distribution of the lengths of genomic segments inverte during the evolutionary divergence of two species cannot be inferred d rectly from the output of genome rearrangement al...
Adrian Maler, David Sankoff, Elisabeth R. M. Tilli...
CORR
2006
Springer
118views Education» more  CORR 2006»
13 years 9 months ago
Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge s
The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated,...
L.-M. Birkholtz, Olivier Bastien, G. Wells, D. Gra...