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» Semantics of Biological Regulatory Networks
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BMCBI
2007
144views more  BMCBI 2007»
13 years 7 months ago
Accelerated search for biomolecular network models to interpret high-throughput experimental data
Background: The functions of human cells are carried out by biomolecular networks, which include proteins, genes, and regulatory sites within DNA that encode and control protein e...
Suman Datta, Bahrad A. Sokhansanj
CMSB
2008
Springer
13 years 9 months ago
A Language for Biochemical Systems
Abstract. CBS is a Calculus of Biochemical Systems intended to allow the modelling of metabolic, signalling and regulatory networks in a natural and modular manner. In this paper w...
Michael Pedersen, Gordon D. Plotkin
NAR
2011
224views Computer Vision» more  NAR 2011»
12 years 10 months ago
KaPPA-View4: a metabolic pathway database for representation and analysis of correlation networks of gene co-expression and meta
Correlations of gene-to-gene co-expression and metabolite-to-metabolite co-accumulation calculated from large amounts of transcriptome and metabolome data are useful for uncoverin...
Nozomu Sakurai, Takeshi Ara, Yoshiyuki Ogata, Ryos...
BMCBI
2007
137views more  BMCBI 2007»
13 years 7 months ago
PlnTFDB: an integrative plant transcription factor database
Background: Transcription factors (TFs) are key regulatory proteins that enhance or repress the transcriptional rate of their target genes by binding to specific promoter regions ...
Diego Mauricio Riaño-Pachón, Sloboda...
RECOMB
2010
Springer
13 years 9 months ago
Algorithms for Detecting Significantly Mutated Pathways in Cancer
Abstract. Recent genome sequencing studies have shown that the somatic mutations that drive cancer development are distributed across a large number of genes. This mutational heter...
Fabio Vandin, Eli Upfal, Benjamin J. Raphael