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BMCBI
2006
203views more  BMCBI 2006»
13 years 7 months ago
Genome-wide prediction of transcriptional regulatory elements of human promoters using gene expression and promoter analysis dat
Background: A complete understanding of the regulatory mechanisms of gene expression is the next important issue of genomics. Many bioinformaticians have developed methods and alg...
Seon-Young Kim, YongSung Kim
IMSCCS
2006
IEEE
14 years 1 months ago
Combining Comparative Genomics with de novo Motif Discovery to Identify Human Transcription Factor DNA-Binding Motifs
Background: As more and more genomes are sequenced, comparative genomics approaches provide a methodology for identifying conserved regulatory elements that may be involved in gen...
Linyong Mao, W. Jim Zheng
APBC
2004
116views Bioinformatics» more  APBC 2004»
13 years 8 months ago
Structure-Function Relationship in DNA Sequence Recognition by Transcription Factors
Transcription factors play essential role in the gene regulation in higher organisms, binding to multiple target sequences and regulating multiple genes in a complex manner. In or...
Akinori Sarai, Samuel Selvaraj, M. Michael Gromiha...
BMCBI
2007
148views more  BMCBI 2007»
13 years 7 months ago
WeederH: an algorithm for finding conserved regulatory motifs and regions in homologous sequences
Background: This work addresses the problem of detecting conserved transcription factor binding sites and in general regulatory regions through the analysis of sequences from homo...
Giulio Pavesi, Federico Zambelli, Graziano Pesole
BMCBI
2006
64views more  BMCBI 2006»
13 years 7 months ago
In silico modelling of hormone response elements
Background: An important step in understanding the conditions that specify gene expression is the recognition of gene regulatory elements. Due to high diversity of different types...
Maria Stepanova, Feng Lin, Valerie C.-L. Lin